A smartphone app designed to tackle the underlying psychological causes of premature ejaculation can significantly improve sex life and delay ejaculation, while offering a way to reduce stigma around the condition, say researchers. It is the first study to test a digital-first approach for treating premature ejaculation at home. The app teaches men several therapeutic techniques, tips and exercises designed by urologists and psychologists, as well as offering evidence-based information to men about the condition. This guided training is designed to help men manage arousal and better control when they ejaculate. It includes mindfulness, arousal awareness exercises and cognitive behavioural therapy, as well as hands-on physical exercises to improve ejaculation control, like the start-stop technique. Men with the condition typically ejaculate sooner than desired during sex and within 60 seconds of penetration. For many men, this leads to worry and performance anxiety and can affect relationships, but the most commonly available treatments, like pills or creams, only limit the symptoms. After 12 weeks, men in the control group – who had been given no other support from the study to manage their condition – were offered access to the app and followed up for 12 weeks. Men in the control group saw an increase of just 0.5 seconds on average. Men using the app reported significantly improved control of their ejaculation during sex, reduced worry linked to ejaculation, and a reduced impact on their relationship. After 12 weeks, 22% of men who used the app were no longer experiencing premature ejaculation, based on self-reported measures. The study's lead researcher, Dr Christer Groeben from Marburg University and Medical Faculty Heidelberg at Heidelberg University, Germany, is presenting the study findings at EAU26. He said, "Many men who live with premature ejaculation don't seek help because of the shame associated with the condition. Our study shows that, as an at-home self-help tool, this can support men to improve control of their ejaculation and achieve a satisfying sex life without losing spontaneity. These men can remain under-treated and live with a considerable psychological burden that really starts to affect the quality of their relationships. Going to a doctor for help can feel like a big first step, and so an app like this can help to bridge that gap by normalising the condition as treatable." Dr Giorgio Russo, Associate Professor of Urology at University of Catania, Italy, and Chair of the EAU Office of Young Academic Urologists, said: "There's much information and misinformation out there for men who find they have premature ejaculation, and so this app is devised by urologists and psychologists as a new way to bring together the most effective advice into a single, easily accessible and trusted, evidence-based resource. The research shows it can completely treat almost a quarter of patients, which is a huge development because these men were treated without pills. I think it would now be interesting to build on this research with a larger study and look at the impact of a digital approach on the satisfaction of partners, rather than just users." The app is available in Ireland, Germany, Austria, Luxembourg, Liechtenstein and Belgium. Discover how Bruker is helping drive innovation in cosmetic science through advanced AFM techniques. Discover how Thermo Fisher is shaping the future of plant-based foods through texture innovation and cultural relevance. Brain microphysiological systems are reshaping in vitro neurotoxicity testing through functional validation and advanced disease modeling. News-Medical.Net provides this medical information service in accordance with these terms and conditions. Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide. Hi, I'm Azthena, you can trust me to find commercial scientific answers from News-Medical.net. Registered members can chat with Azthena, request quotations, download pdf's, brochures and subscribe to our related newsletter content. A few things you need to know before we start. While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles. Please do not ask questions that use sensitive or confidential information.

A new University of Utah-led study has discovered the mechanism behind a decades-old evolutionary mystery-how "selfish chromosomes" cheat the rules of genetic inheritance. Normally, Ovd detects and eliminates abnormal sperm cells. This is the first time that the same gene has been shown to be crucial for eliminating gametes by multiple independent selfish chromosomes. It indicates that evolutionarily distant selfish chromosomes may often converge on shared cellular processes." Jackson Ridges, U biologist and lead author of the study Since then, the phenomenon has been found across the animal kingdom, from nematodes to mammals, yet its underlying mechanisms have remained unknown. While humans lack an exact genetic equivalent, a similar quality-control process may exist that uses different machinery. "How selfish genes can cause sterility has been a long-standing mystery in field of speciation," said Nitin Phadnis, associate professor at the U and senior author of the study. "By going for a deep understanding of how Overdriveworks, we inadvertently opened up entirely new directions of research into understanding the mechanisms of cellular quality control systems, and how sterility emerges between young species." Nearly 20 years ago, then grad student Phadnis and mentor H. Allen Orr first identified Ovd as an element in male sterility and segregation distortion in hybrids between two Drosophila species. Their 2009 paper revealed that the gene could block competing sperm from forming. The findings led to widespread acceptance that segregation distorters can drive reproductive isolation between species. He explored other topics as a post doc, but Ovd never left his mind. "A big question in evolutionary genetics is, 'What is the engine that drives genes to evolve such that organisms diverge into new species-internal genetic conflict or organismal adaptation? First, the researchers tackled whether Ovd was essential to sperm production. "I wanted to look for a way that we can show this isn't just some weird selfish chromosome stuff going on. This is a genuine physiological phenomenon that we're investigating," Ridges said. The group knocked out the Ovd gene in D. pseudoobscura and D. melanogaster to test two different, completely independent selfish chromosomes. Surprisingly, they observed no difference in male fertility, establishing that the gene isn't necessary for sperm production in either species. The P53 gene's role in cancer came to mind. P53 works as a safeguard to stop runaway cell reproduction. Flies without P53 are fine unless there's a problem to genome integrity. "Maybe Ovd's only role is to recognize damage and remove those cells. But if there's no damage, everything's fine without it," Ridges said. "It was the primary way we could connect all these findings that didn't make intuitive sense, at first." To test their theory, they used a well-known temperature threshold beyond which fruit flies can't reproduce. At temperatures greater than 31º C, all male Drosophila go sterile, but no one knew why. After exposing normal flies and flies without Ovd to a high-temperature bacterial incubator for one week, the normal fly stock was sterile while the males without Ovd produced progeny. "That doesn't mean Overdrive is the selfish gene-it's just being hijacked." The team's next steps are to knock out Overdrive in different Drosophila species to assess how many other selfish chromosomes in different species operate through this system of hijacking the Overdrive checkpoint. They're also investigating if segregation distortion occurs in human lineages. Selfish chromosomes exploit a germline checkpoint to eliminate competing gametes. Discover how Bruker is helping drive innovation in cosmetic science through advanced AFM techniques. Discover how Thermo Fisher is shaping the future of plant-based foods through texture innovation and cultural relevance. Brain microphysiological systems are reshaping in vitro neurotoxicity testing through functional validation and advanced disease modeling. News-Medical.Net provides this medical information service in accordance with these terms and conditions. Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide. Hi, I'm Azthena, you can trust me to find commercial scientific answers from News-Medical.net. Registered members can chat with Azthena, request quotations, download pdf's, brochures and subscribe to our related newsletter content. A few things you need to know before we start. While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles. Please do not ask questions that use sensitive or confidential information.

Specialist resource centers (a form of 'Inclusion Base') within mainstream secondary schools may be linked to stronger academic progress, improved attendance, and a greater sense of belonging for autistic pupils, according to a new three-year study from the University of Surrey. However, the research suggests that placement alone does not determine wellbeing. Researchers followed 119 autistic pupils, aged 11–14 years old, across seven mainstream secondary schools, comparing three types of provision: placement in a specialist resource center(SRC), mainstream placement in a school that hosted an SRC, and mainstream schools without an SRC. Outcomes were compared across psychological wellbeing, social inclusion, belonging, academic progress, attendance and exclusion. For some autistic pupils, mainstream school environments can be overwhelming due to noise, sensory demands and social pressure. Specialist resource centers offer a quieter, more supportive space, with higher staff to student ratios helping pupils stay engaged in their education." Researchers found that while autistic pupils in SRCs had similar levels of wellbeing to those in other types of schools, specialist resource centres did show potential advantages in key areas including higher academic attainment, stronger sense of school belonging, higher perceived teacher support and smaller attendance gaps (relative to whole-school averages) compared to national benchmarks for autistic pupils. Interestingly supportive relationships were the strongest predictors of positive outcomes. Perceived peer support was most strongly associated with reduced internalising symptoms, fewer peer problems, greater happiness, stronger friendships and increased flourishing. "Debates around inclusive education often focus on whether autistic pupils should be educated in specialist or mainstream settings. Policy decisions focused solely on placement will always be incomplete. Specialist resource centres may offer advantages – particularly for belonging and academic equity – but what matters most is whether schools cultivate supportive relationships and autism-affirming environments. "Improving outcomes for autistic pupils may depend less on where they are educated, and more on how well they are supported within that setting." This study was published in the journal Autism. Discover how Bruker is helping drive innovation in cosmetic science through advanced AFM techniques. Discover how Thermo Fisher is shaping the future of plant-based foods through texture innovation and cultural relevance. Brain microphysiological systems are reshaping in vitro neurotoxicity testing through functional validation and advanced disease modeling. News-Medical.Net provides this medical information service in accordance with these terms and conditions. Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide. Hi, I'm Azthena, you can trust me to find commercial scientific answers from News-Medical.net. Registered members can chat with Azthena, request quotations, download pdf's, brochures and subscribe to our related newsletter content. A few things you need to know before we start. While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles. Please do not ask questions that use sensitive or confidential information.

Cells behave like cities and organelles carry out infrastructural roles: Mitochondria are powerhouses, the endoplasmic reticulum serves as a transport hub and lysosomes help with waste disposal. Communication between different parts of a cell is important for metabolism. This inter-organelle communication can occur at sites where these parts are in contact with each other, known as membrane contact sites. One of the most abundant interactions occurs at the endoplasmic reticulum and mitochondria contact sites, or ERMCS, and dysregulation leads to various diseases, including neurodegeneration, obesity, cancer and diabetes. However, little is known about what drives ERMCS organization. In a new study, University of Michigan researchers found that the FDA-approved drug fedratinib can lead to ERMCS formation, providing a potential therapeutic avenue. Using human and mouse cell lines, the researchers screened a library of FDA-approved drugs to see which ones can influence ERMCS formation. They found that the anti-cancer drug fedratinib could do so, and this increase was reversible when fedratinib was washed away from the cells. The team found that fedratinib inhibits BRD4, a protein that controls how DNA is read by the cells in a process called transcription. This inhibition activates a transcriptional pathway that induces ERMCS formation. By identifying this signaling pathway, we can better understand how these contact sites are sustained." These changes were similar to what is seen when cells are infected with SARS-CoV-2 and in metastatic melanoma cells. "There were also different populations of mitochondria that differed in their degree of contact with the endoplasmic reticulum." Approximately 30% of the mitochondria exhibited structural alterations, and the researchers believe that those with abundant contact sites are being used to support specific metabolic pathways. They also aim to understand how these mitochondria are affecting metabolic processes and whether they have similar roles in other diseases. BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes. Discover how Bruker is helping drive innovation in cosmetic science through advanced AFM techniques. Discover how Thermo Fisher is shaping the future of plant-based foods through texture innovation and cultural relevance. Brain microphysiological systems are reshaping in vitro neurotoxicity testing through functional validation and advanced disease modeling. News-Medical.Net provides this medical information service in accordance with these terms and conditions. Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide. Hi, I'm Azthena, you can trust me to find commercial scientific answers from News-Medical.net. Registered members can chat with Azthena, request quotations, download pdf's, brochures and subscribe to our related newsletter content. A few things you need to know before we start. While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles. Please do not ask questions that use sensitive or confidential information.

First published in 2010, the EULAR recommendations for the management of RA, the most frequent inflammatory rheumatic disease, have been relied upon by healthcare professionals and organizations worldwide to offer an up-to-date and robust analysis of the effectiveness and practical use of available DMARDs – from conventional agents such as methotrexate to biologics and Janus kinase (JAK) inhibitors. The recommendations were last reviewed in 2022 to include key safety factors. Although there have been no new drugs approved since the last version, deepened insights as well as important strategic developments have accumulated. Researchers, healthcare professionals, and patients from around the world worked together to develop this new advice. Of note, there are now fewer recommendations – a total of 9, down from 11 in the 2022 version – with one previous recommendation being removed, and two merged. The overarching principles state – as in earlier iterations – that rheumatologists are the specialists who should primarily care for people with RA. They also restate the aim for best care, which includes shared decision-making between the patient and the rheumatologist based on disease activity and safety as well as patient factors such as comorbidities or progression of structural damage. There are multiple drugs with different modes of action, and people may require multiple successive therapies throughout their life to control their disease. Finally, RA has a high individual, medical, and societal cost, all of which should be considered in its management. They go on to consider treatment targets and monitoring frequency, as well as the specific role for methotrexate, glucocorticoids, biologics, and JAK inhibitors – the only group of targeted synthetic DMARDs approved for RA – including what to do if treatment targets are not achieved, or if a patient is in sustained remission. An important change in the current update is the omission of stratification according to risk factors for bad outcome once the initial treatment strategy has failed, since that failure is already such a risk factor. While the authors acknowledge the developing field around pre-RA, this has not yet matured to allow for a respective new recommendation. Also of note, the previous recommendations advised that, after glucocorticoids had been discontinued and a patient was in sustained remission, DMARD dose reduction could be considered; the new formulation adds in a preference for DMARD continuation in this situation, although dose reduction may still be considered. "A cure for RA is still rare, and for most patients stopping treatment altogether leads to the disease flaring, especially for patients on biologic or JAK inhibitor therapies" said Christopher Edwards – co-convenor of the task force, EULAR board member and Professor at the University of Southampton, United Kingdom. "While carefully reducing medication can be successful for some people, completely stopping treatment is generally not advised. The updated recommendations continue to highlight that treatment decisions should be made jointly by patients and clinicians, ensuring that care is tailored to each individual's needs and preferences." EULAR hopes the updated and streamlined recommendations will support therapeutic decisions for people living with RA. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biologic disease-modifying antirheumatic drugs: 2025 update. Discover how Bruker is helping drive innovation in cosmetic science through advanced AFM techniques. Discover how Thermo Fisher is shaping the future of plant-based foods through texture innovation and cultural relevance. Brain microphysiological systems are reshaping in vitro neurotoxicity testing through functional validation and advanced disease modeling. News-Medical.Net provides this medical information service in accordance with these terms and conditions. Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide. Hi, I'm Azthena, you can trust me to find commercial scientific answers from News-Medical.net. Registered members can chat with Azthena, request quotations, download pdf's, brochures and subscribe to our related newsletter content. A few things you need to know before we start. While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles. Please do not ask questions that use sensitive or confidential information.

COPD is the third commonest cause of death globally. It also creates massive economic costs and a recent study estimated that the global economic burden from COPD will amount to $US40 trillion by 2050. Many patients remain undiagnosed and spirometry is essential to confirm the diagnosis. However, for more than 30 years there has been an unproductive debate about how the results of spirometry should be interpreted to confirm the diagnosis in symptomatic patients. The divergent recommendations about spirometry interpretation have confused primary and secondary care clinicians, as well as lung specialists, leading to the perception that spirometry is a difficult test to perform and interpret, and underuse of the test. GOLD and GLI have now agreed how spirometry should be interpreted to confirm the diagnosis resolving the confusion. They also agree that performing spirometry is not difficult and more tests need to be done. Working with GLI to agree how spirometry should be interpreted to confirm the diagnosis is an important step forward in addressing the huge levels of underdiagnosis of COPD globally. Both organisations are clear that more spirometry tests need to be performed and we hope that making its interpretation simple will help with this." Professor David Halpin, member of the GOLD Board & Science Committee Joint statement from GOLD/GLI regarding the use of spirometry to define airflow obstruction and diagnose COPD. Discover how Bruker is helping drive innovation in cosmetic science through advanced AFM techniques. Discover how Thermo Fisher is shaping the future of plant-based foods through texture innovation and cultural relevance. Brain microphysiological systems are reshaping in vitro neurotoxicity testing through functional validation and advanced disease modeling. News-Medical.Net provides this medical information service in accordance with these terms and conditions. Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide. Hi, I'm Azthena, you can trust me to find commercial scientific answers from News-Medical.net. Registered members can chat with Azthena, request quotations, download pdf's, brochures and subscribe to our related newsletter content. A few things you need to know before we start. While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles. Please do not ask questions that use sensitive or confidential information.

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London has found that excessive smartphone use is closely associated with disordered eating, including uncontrolled eating and emotional overeating, as well greater symptoms of food addiction in young people with no diagnosis of an eating disorder. The research, published in the Journal of Medical Internet Research, established a significant and consistent association between Problematic Smartphone Use (PSU) - whereby an individual becomes behaviorally or psychologically reliant on their smartphone - and eating disorder symptom severity. Researchers argue this highlights the need for early intervention strategies specific to excessive phone use for young people displaying eating disorder symptoms. While there has been research conducted into the negative impact that problematic internet usage, exposure to social media, and harmful online content can have on body image and body dysphoria in both clinical and non-clinical populations, none have specifically examined PSU. The studies were from across the globe and provided researchers with a sample size of 52,584 participants with an average age of 17. Their analysis of the data found that higher daily smartphone use was also related to greater food addiction symptoms, broader disordered eating behaviours like uncontrolled eating or emotional overeating, and body dissatisfaction in people with no diagnosis of an eating disorder. The association was particularly strong in those who use their phones for more than seven hours a day. Ben Carter, Professor of Medical Statistics at King's IoPPN and the study's senior author said, "Smartphones have become ubiquitous in our everyday lives. It is apparent from our study that, even for people without a diagnosis of an eating disorder, the overuse of a smartphone is associated with poor body satisfaction and altered eating behaviours, and is a potential source of distress" While smartphones might present an easy way for this to happen, being consistently exposed to idealised images can lead them to compare their own appearance with these "standards", leading to poor self-esteem and appearance dissatisfaction - both risk factors for the development of an eating disorder." Dr. Johanna Keeler, a Visiting Lecturer at King's IoPPN and study's first author Discover how Bruker is helping drive innovation in cosmetic science through advanced AFM techniques. Discover how Thermo Fisher is shaping the future of plant-based foods through texture innovation and cultural relevance. Brain microphysiological systems are reshaping in vitro neurotoxicity testing through functional validation and advanced disease modeling. News-Medical.Net provides this medical information service in accordance with these terms and conditions. Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide. Hi, I'm Azthena, you can trust me to find commercial scientific answers from News-Medical.net. Registered members can chat with Azthena, request quotations, download pdf's, brochures and subscribe to our related newsletter content. A few things you need to know before we start. While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles. Please do not ask questions that use sensitive or confidential information.